Sample analysis

Across our network of 12 laboratories in 3 locations, Synexa offers the technical skills and capacity to handle everything from small pre-clincial R&D studies to large Phase III clinical trial sample analysis.

As a specialist in custom-built solutions, Synexa has developed expertise in the analysis of a very wide range of biomarker types drawn from almost any matrix available.

Analytical Technologies Include:

Immunoassays

  • ELISA
  • Meso Scale Discovery (Electrochemiluminescence)
  • Cytometric Bead Array
  • Nephelometry
  • Fluorescence and Luminescence
  • NanoString

Flow cytometry

  • 8 and 10-colour BD FACS Canto II
  • FlowJo analysis platform
  • Automated processing systems

Culture-based assays

  • Flow Cytometry
  • ELISpot
  • Sample preparation and automated nucleic acid extraction
  • Quantitative real-time PCR
  • Affymetrix DNA microarrays
  • DNA sequencing
  • Nanostring Gene Expression
  • NanoString CNV and gene fusion analysis

Bioanalytical Chemistry

  • Extraction from matrices such as serum, plasma, saliva, urine and CSF by solid phase extraction (SPE), liquid-liquid extraction (LLE) or precipitation.
  • Quantification using Photodiode Array (PDA), Evaporative Light Scatter (ELS) and Triple-Quad Mass Spectrometry (LC-MS/MS).
  • Quantification by High Resolution Mass Spectrometry (Triple-ToF) and NMR are performed in collaboration with the Central Analytical Facility of The University of Stellenbsoch.

Liquid Biopsy Analysis

  • Parsortix cell capture technology
  • NanoString based expression an analysis
  • rtPCR and NGS
  • Fluorescent Microscopy
  • Nanostring-Based expression analysis