Biomarker Solutions
Biomarker
Solutions
Innovative biomarker solutions for clinical investigation
Synexa’s experience in providing biomarker solutions for complex applications is unapparelled in the industry. Our scientists are experts in finding the optimum analytical strategy for biomarker detection, analysis and data interpretation and our method development and validation strategies are guided by industry guidelines to provide data that is clinically-relevant and of the highest quality and value.
We pride ourselves in providing deep insight, drawn from our years of experience as pioneers in the field of biomarker science, into what the data means for your study and how the data can be applied to advancing your therapeutic along its development pipeline.
Synexa’s global setup aims to support research programs from preclinical translational research through to late stage clinical trials and post-marketing surveillance.
Services
Overview
Biomarker Strategy
Synexa has extensive experience in designing biomarker strategies to support clients’ broader clinical development objectives. Working collaboratively with our clients, we focus on careful selection of markers to ensure results that support decision making and a significant return on investment.
Biomarkers play an integral role in new drug developments by providing valuable information to facilitate the decision making process of new therapies. Biomarker-based stratification can be used to enrich clinical populations, reducing cost and trial duration.
Our specialised biomarker services include:
- Advice on the optimal selection of biomarkers in the context of the drug, disease and budget.
- Development, optimization and validation of biomarker assays across a wide range of matrices and technology platforms.
- Biomarker analysis of clinical samples for exploratory or clinical trial settings.
- Interpretation of results and advice on key outcomes and decisions to be made about candidate therapies.
Our biomarker strategies encompass the full biological spectrum, including DNA, RNA, protein, cell and tissue analysis, matched with proven and trusted technology platforms:
DNA
- Targeted PGx
- Microarray
- Sequencing
- Electrophoresis
RNA
- NanoString
- RT-qPCR
- PCR expression array
Protein
- ELISA, CBA & MesoScale
- ELISpot
- Protein arrays
- Nephelometry
- Fluorescence and luminescence based assays
Cell
- Flow cytometry
- Sorting
- Cell Culture assays
- Circulating Tumor Cells (CTC)
- Fluorescence Microscopy
- Microbiology
Tissue
- NanoString
- Organotypic culture
Custom solutions & Novel modalities
As the medical field advances, promising novel therapeutic targets and drug modalities are regularly under investigation, requiring highly specific, high quality scientific research expertise.
At Synexa, we specialize in providing bespoke assay development, validation and production, providing quality results, customised to your specific requirements. Our scientists have unrivalled experience in the investigation of novel drug modalities and the development of custom assays to meet and resolve the key clinical endpoints under investigation.
Other capabilities include:
- Single or Multiplex assay development
- Flow cytometry
- MSD discovery assays/Chemiluminescence assays
- Receptor occupancy assays
We use innovative, industry-proven and trusted technology platforms to ensure we provide only best data for your purpose.
