https:\/\/www.nature.com\/articles\/s41467-020-15309-6<\/a>) uncovered an essential role for induced Treg (iTreg) cells expressing specific V\u03b2 chains in preventing autoimmunity upon viral triggers. LCMV infection induces a type I interferon-dependent loss of Treg cells, which is rapidly compensated for by the conversion of high-affinity V\u03b25+ conventional T cells into iTreg cells. While these V\u03b25+ iTreg cells do not play a role in limiting the anti-viral immune response, they are essential for suppression of colitogenic CD8+ effector T cells at the gut barrier site. In humans, this role is fulfilled by V\u03b22+ Treg cells, which are specifically expanded in IBD patients with inactive disease. Their results support the concept that the Treg compartment as a whole is able to adapt to inflammatory insults that may compromise peripheral tolerance.<\/p>\nSynexa Life Sciences offers a wide range of panels to assess T cell functional profiles to support clients in pre-clinical and clinical research.\u00a0 We offer a comprehensive array of flow cytometry, soluble biomarker and genetic assays to measure a multitude of relevant markers in a clinical setting.<\/p>\n","protected":false},"excerpt":{"rendered":"
Regulatory T (Treg) cells are important for the induction and maintenance of peripheral tolerance; therefore, they are key in preventing excessive immune responses and autoimmunity and are responsible for maintaining homeostasis. Treg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), including <\/p>\n","protected":false},"featured_media":2190,"parent":0,"menu_order":0,"template":"","format":[],"sf_category":[12],"sf_tags":[44,55,76,77],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/strong_foundations\/2189"}],"collection":[{"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/strong_foundations"}],"about":[{"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/types\/strong_foundations"}],"version-history":[{"count":0,"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/strong_foundations\/2189\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/media\/2190"}],"wp:attachment":[{"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/media?parent=2189"}],"wp:term":[{"taxonomy":"sf_category","embeddable":true,"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/sf_category?post=2189"},{"taxonomy":"sf_tags","embeddable":true,"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/sf_tags?post=2189"},{"taxonomy":"format","embeddable":true,"href":"https:\/\/synexagroup.com\/wp-json\/wp\/v2\/format?post=2189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}