Biomarker Science
Synexa works in a collaborative manner with clients to provide customized, flexible and multi-faceted biomarker solutions. The Analytical Continuum is a vital framework for the evolution of a robust biomarker program from Strategy to Stratification.
The analytical continuum
Strategy
Crafting a plan to achieve long-term clinical objectives under conditions of biological uncertainty.
Pre-Analytical
Control of the phase and process between specimen collection and initiation of analysis that ensures robust representation of in vivo biology.
Analytical
Convergence of excellence in the scientists, methodologies and instrument controls brought to focus on the processing and acquisition of biological specimens.
Data Analytics
Analysis of raw data to draw conclusions, generate information and develop insight.
Stratification
Division of patients into predictive subgroups based upon response to therapy.
Technologies
Our technology platforms are tailored to assess biomarkers across the biological continuum.
We use innovative approaches and validated equipment to answer client-specific questions related to biomarkers at each level of the biological continuum.
This systems biology approach allows a much deeper insight into the drug-target interactions at a molecular level, defining the mechanism of action through the continuum and the ultimate response at tissue level.
DNA
- Targeted PGx
- Microarray
- Sequencing
- Electrophoresis
RNA
- NanoString
- RT-qPCR
- PCR expression array
Protein
- ELISA, CBA & MesoScale
- ELISpot
- Protein arrays
- Nephelometry
- Fluorescence and luminescence based assays
Cell
- Flow cytometry
- Sorting
- Cell Culture assays
- Circulating Tumor Cells (CTC)
- Fluorescence Microscopy
- Microbiology
Tissue
- NanoString
- Organotypic culture
DNA
- Targeted PGx
- Microarray
- Sequencing
- Electrophoresis
RNA
- NanoString
- RT-qPCR
- PCR expression array
Protein
- ELISA, CBA & MesoScale
- ELISpot
- Protein arrays
- Nephelometry
- Fluorescence and luminescence based assays
Cell
- Flow cytometry
- Sorting
- Cell Culture assays
- Circulating Tumor Cells (CTC)
- Fluorescence Microscopy
- Microbiology
Tissue
- NanoString
- Organotypic culture