Autoimmune Biomarker Services for Drug Development
Expert biomarker and bioanalytical solutions driving the development of therapeutics for autoimmune conditions.
Autoimmune Expertise
Synexa specialises in autoimmune biomarker and bioanalytical services, tailored to both the therapeutic modality and the specific disease area. Autoimmune diseases are highly heterogeneous, affecting multiple cell types, molecular pathways and tissues.
To address this complexity, we deliver integrated, multi-platform solutions that combine advanced technologies to support biomarker discovery, patient stratification and therapeutic development in autoimmune research.
Expert Solutions for Autoimmune Therapeutics
Translational Science for Autoimmune Research
Synexa’s translational solutions are designed to bridge mechanistic insight with clinical relevance in autoimmune disease. By integrating high-quality biospecimens with validated biomarker and immunoprofiling platforms, we enable confident target validation, patient stratification and early proof of mechanism. Our approach supports informed decision-making across preclinical and clinical development, grounded in robust human data.
Flow Cytometry for Immune Profiling
Synexa’s flow cytometry panels include immune cell phenotypic markers, activation markers, intracellular cytokine production and specific receptors to measure target engagement and receptor occupancy.
Our specialised flow cytometry team are experts in performing biomarker discovery studies to better stratify patients with disease as well as track disease progression and flare ups over time. Samples can include fresh whole blood with optimised extended stability and PBMC’s.
Advanced Biomarker Analysis for Autoimmune Diseases
In addition to large molecule bioanalysis, Synexa has significant experience in designing and analysing bespoke biomarker panels for autoimmune conditions. These include:
- Highly sensitive quantification of 10-analyte cytokine panels using the MSD platform
- Broader semi-quantitative 92-analyte panels using the Olink platform
- Complement component analysis
- Autoantibody profiling
Genomics and Gene Expression Insights
Genetic analysis is a key component in autoimmune research, providing detailed insight into multiple sample types, even those with limited material. Quantification of the frequency of single nucleotide polymorphism (SNP) expression is pertinent in those diseases where such alterations significantly contribute to disease pathology. In cases where casual SNPs are unknown, Synexa can further support targeted gene sequencing.
Synexa utilises the powerful NanoString platform and nCounter panels to quantify gene expression of over 750 markers in blood and tissue samples. Panels include broader inflammatory panels which can provide insight into Th1 vs Th2 responses and interferon signatures in multiple sample types.
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