Flow Cytometry Assay Services
Robust, bespoke flow cytometry assays designed to your specific requirements
Illuminating Insights
At Synexa we create robust, bespoke flow cytometry panels, custom-designed to meet customer-specific needs and requirements.
We offer a comprehensive suite of advanced assays, including immunophenotyping assays, target engagement PK/PD assays as well as an array of functional assays. Our flow cytometry assays are validated according to the highest standards, including the Clinical and Laboratory Standards Institute’s (CLSI) H62 Validation of Assays Performed by Flow Cytometry guidelines, ensuring that our assays deliver accurate, reproducible results and meet regulatory requirements and best practices.
Our global lab capabilities extend to processing clinical samples from diverse matrices (fresh or cryopreserved) and are strategically positioned to ensure customers receive high-quality, scientifically robust clinical data to advance their drug development pipelines.
Analytical Assay Capabilities:
Each of our assays can be fully customised according to needs and endpoint objectives. Synexa offers full sample management throughout the complete analytical cycle, with dedicated project, logistics and sample management policies.
Immuno-profiling & Phenotyping Assays
- Lymphocytes (TN, TH, TFH, Treg, TEFF, TEM, TCM, NK & B cells)
- Dendritic cells (DCs)
- Monocytes
- Macrophages
- Myeloid-derived suppressor cells (MDSCs)
- Multimers
- Intracellular staining
- Treg polarisation assessment
Target Engagement/PK/PD Assays
- Receptor occupancy assays
- Phospho-flow assays
- Polyamine uptake assessment
- SARS-CoV-2 immune response assessment
- Flow cytometry-based PK assessment
Functional Assays
- Cytokine expression
- Cytotoxic markers
- Activation markers
- Proliferation assays
- Basophil degranulation
- Rare cell detection and quantification
- Antibody-dependant cellular cytotoxicity (ADCC)
- Complement-dependant cytotoxicity (CDC)
- Small particle detection and analysis
Robust Flow Cytometry Platforms
In the development of your custom flow cytometry assays, we use technology platforms that are robust, reliable and reputable in the clinical field and provide comprehensive and detailed data readouts for your application.
BD FacsLyric (12 colours)
Cytoflex (13 colours)
BD FACSymphony A3 (28 colours)
FAQ
Can Synexa's flow cytometry panels be tailored to the exact biomarkers our study needs?
Synexa offers fully bespoke, custom-designed flow cytometry panels tailored to customer-specific needs and endpoints, including robust assay development, validation, and full analytical support.
Which regulatory or industry guidelines does Synexa follow for flow cytometry method validation?
Our flow cytometry assays are validated according to the Clinical and Laboratory Standards Institute (CLSI) H62 – Validation of Assays Performed by Flow Cytometry guidelines to ensure accuracy, reproducibility, and regulatory alignment.
What sample types does Synexa support for flow cytometric analysis?
Synexa works with a variety of matrices including whole blood, PBMCs (fresh and cryo-preservd), tissue dissociates and rare cell populations.
What are Synexa's quality control approaches?
Synexa’s Quality control (QC) processes are embedded at every stage and include daily instrument QC, performance tracking, and participation in external proficiency testing programs.
What functional assays does Synexa provide?
Synexa offers Cytokine production, degranulation, proliferation, activation marker induction, and cytotoxicity assays (ADCC/CDC).
Improving the quality of human health
Contact us
Discuss biomarker and bioanalytical solutions to accelerate your therapeutic pipeline
