Mass Spectrometry Services
Expert mass spectrometry solutions to progress your clinical research pipelines.
- Services
- Mass Spectrometry
Optimised LC-MS/MS Solutions
Synexa delivers advanced LC-MS/MS and LC-UV bioanalysis through Alderley Analytical, acquired in 2024. Originally a spin-out from AstraZeneca and ICON, the team brings a personal, responsive approach to high-quality regulated and discovery-phase studies.
Operating from a custom-built, 16,500 sqft facility near Manchester Airport, we support TK, PK, ADA, biomarker, and formulation endpoints across small molecules, peptides, oligonucleotides, proteins, and ADCs. All assays are developed and validated to ICH M10 standards across multiple matrices, with full GLP/GCP compliance.
Our 9 LC-MS/MS instruments include Waters and Sciex platforms, backed by WATSON LIMS and WINNONLIN for toxicokinetic analysis. With rapid turnaround and scalable capacity, we provide dependable support from early discovery through to clinical development.
Mass Spectrometry Bioanalytical Services
Clinical Bioanalysis
Robust, regulatory-compliant quantification of drugs, metabolites, or biomarkers in clinical trial samples to support PK/PD and therapeutic monitoring.
GLP Bioanalysis
High-integrity, GLP-compliant bioanalytical services for non-clinical safety and toxicokinetic studies, ensuring data traceability and regulatory readiness.
Discovery Bioanalysis
Rapid, fit for purpose bioanalytical support for early-stage drug discovery, enabling lead optimisation and preclinical decision-making.
Non-regulated Bioanalysis
Agile bioanalytical support for early-stage research, enabling rapid decision-making in lead optimisation, PK screening, and biomarker exploration.
LC-MS/MS Techniques:
Each assay can be fully customised according to needs and endpoint objectives. Synexa offers full sample management throughout the complete analytical cycle, with dedicated project, logistics and sample management policies.
- Molecules
Small molecules
Peptides
Oligonucleotides
Proteins
Protein degraders
Biomarkers
ADC’s
- Extraction Methods
Protein precipitation
Lipid removal
Solid phase
Liquid-liquid
Supported liquid
Protein digestion
Immunoaffinity
- Chromatography
Reverse phase
Hilic
Ion-pair
Chiral
- DDI Studies
Extensive experience supporting DDI studies
Assays validated to M10 and M12 guidelines
LC-MS/MS Platforms
Our technology platforms are robust, reliable and reputable in the clinical field and provide comprehensive and detailed data readouts for your application.
Waters T-QS LC-MS/MS
Sciex 6500+
Waters Premier I-Class UPLC
