Mass Spectrometry Services

Expert mass spectrometry solutions to progress your clinical research pipelines

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Optimised LC-MS/MS Bioanalytical Solutions

Synexa delivers advanced LC-MS/MS and LC-UV bioanalysis solutions from a custom-built 16,500 sqft UK facility near Manchester Airport. We support TK, PK, ADA, biomarker, and formulation endpoints across small molecules, peptides, oligonucleotides, proteins, and ADCs. All assays are developed and validated to ICH M10 standards across multiple matrices, with full GLP/GCP compliance.

Our 9 LC-MS/MS instruments include Waters and Sciex platforms, backed by WATSON LIMS and WINNONLIN for toxicokinetic analysis. With rapid turnaround and scalable capacity, we provide dependable support from early discovery through to clinical development.

bioanalysis

Mass Spectrometry Bioanalytical Services

Clinical Bioanalysis

Robust, regulatory-compliant quantification of drugs, metabolites, or biomarkers in clinical trial samples to support PK/PD and therapeutic monitoring.

biomarker samples in an assay panel being inserted into a bioanalytical platform for the purposes of bioanalysis

GLP Bioanalysis

High-integrity, GLP-compliant bioanalytical services for non-clinical safety and toxicokinetic studies, ensuring data traceability and regulatory readiness.

Discovery Bioanalysis

Rapid, fit for purpose bioanalytical support for early-stage drug discovery, enabling lead optimisation and preclinical decision-making.

Non-regulated Bioanalysis

Agile bioanalytical support for early-stage research, enabling rapid decision-making in lead optimisation, PK screening, and biomarker exploration.

LC-MS/MS Techniques

Each assay can be fully customised according to needs and endpoint objectives. Synexa offers full sample management throughout the complete analytical cycle, with dedicated project, logistics and sample management policies.

Custom Assay Development

Molecules

  • Small molecules

  • Peptides

  • Oligonucleotides

  • Proteins

  • Protein degraders

  • Biomarkers

  • ADCs

Extraction Methods

  • Protein precipitation

  • Lipid removal

  • Solid phase

  • Liquid-liquid

  • Supported liquid

  • Protein digestion

  • Immunoaffinity

Chromatography

  • Reverse phase

  • Hilic

  • Ion-pair

  • Chiral

DDI Studies

  • Extensive experience supporting DDI studies
  • Assays validated to M10 and M12 guidelines

LC-MS/MS Platforms

Our technology platforms are robust, reliable and reputable in the clinical field and provide comprehensive and detailed data readouts for your application.

Waters T-QS LC-MS/MS

Sciex 6500+

Waters Premier I-Class UPLC

FAQ

Where is Synexa's mass spectrometry site located?

Synexa’s LC-MS/MS facility is situated near Manchester, UK, and is conveniently located 15 minutes from Manchester Airport, making it easily accessible for receiving domestic and international samples.

Lead times are dictated by the critical reagent purchase time; however, method development can commence as soon as 6 weeks after the contract signature.

Synexa’s Manchester lab houses:

  • 2x Waters Premier IClass UPLC with Xevo TQ-Absolute Triple Quad mass spectrometer
  • 3x Sciex 6500 mass spec with Exion UHPLC System
  • 3x Waters TQ-S Mass spec with IClass UPLC
  • 1x Waters TQ-D mass spec with CTC autosampler

Yes, several assays have been validated to regulatory guidelines, measuring unique signature peptides by LC-MS/MS following protein digestion and SPE extraction.

Small to medium-sized oligonucleotides can be quantified by LC-MS/MS. Oligonucleotides are extracted from the biological matrix using a Rapizyme pretreatment, followed by SPE cleanup and analysis on the low-bind Premier UPLC system with a Waters Xevo TQ-Absolute mass spectrometer.

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