Synexa Insights
The Latest Insights From Our Scientists
Th17 Cells and IL-17: a possible link between inflammation and neuronal decline in Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS). A major component of the immunopathology of MS is the…
Spot on: Use of Dried Blood Spots (DBS) for serological immunoassays
Serological immunoassays provide a complementary approach to PCR-based molecular diagnostics in the detection and monitoring of the immune response of…
Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain
Inflammatory pain and hyperalgesia are considered functional features of an immune response, intended to protect tissue from further damage. At…
The prospect of immunotherapy for combating Alzheimer’s disease
Alzheimer’s disease is a progressive incurable neurodegenerative disorder that often leads to dementia, loss of motor function and cognitive decline.…
Rapid expansion of Treg cells protects from collateral colitis following a viral trigger
Regulatory T (Treg) cells are important for the induction and maintenance of peripheral tolerance; therefore, they are key in preventing…
Immune biomarkers in depression
The identification of clinically relevant and reproducible biomarkers in the field of psychiatry has received increased attention recently in order…
Faecal Calprotectin as a biomarker in Crohn’s disease
Crohn’s disease is an inflammatory bowel disease, which causes inflammation of your digestive tract with symptoms such as abdominal pain,…
Immune checkpoint inhibitors and MDSCs
The development of immune checkpoint inhibitors (ICIs) targeting lymphoid cells has remarkedly transformed therapeutic approaches for the treatment of cancer.…
Potential concussion biomarkers discovered in circulating blood after brain injury
Concussions are a commonly diagnosed injury in many sports, particularly at college or professional levels. While the diagnosis of a…
Complement C4 Genes and Sex-Biased Disease Susceptibility
There are many examples of diseases in which there is a sex bias, however, the underlying biology of this bias…
A unifying expression signature for SLE
Systemic Lupus Erythematosus (SLE) is an inflammatory autoimmune condition characterised by a wide variety of symptoms including skin rashes, oral…
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