Pharmacokinetic (PK) & Toxicokinetic (TK) Services
End-to-end PK/TK services supporting small and large molecules from discovery to clinical trials.
Pharmacokinetic (PK) and Toxicokinetic (TK) Bioanalytical Services
Synexa delivers comprehensive PK and TK bioanalytical services, supporting small molecules, biologics, peptides, oligonucleotides, ADCs, and advanced therapies from discovery through to regulatory submission.
Our services are designed for both non-clinical (GLP) and clinical (GCP) studies, with a strong focus on scientific rigour, regulatory compliance, and rapid turnaround.
PK/TK Applications
Clinical Pharmacokinetics
Quantitative analysis of drugs and metabolites to support Phase I–III clinical trials, including biosimilars and biobetters.
Non-Clinical Toxicokinetics
Comprehensive TK support for IND-enabling and regulatory safety studies.
Complex Modalities
Expertise across:
- Oligonucleotides
- Antibody-drug conjugates (ADCs)
- PROTACs
- Radiopharmaceuticals
- Cell and gene therapies
Data Analysis and Modelling
Advanced PK/TK modelling and reporting using WINNONLIN and Watson LIMS.
Custom Method Development
Rapid assay development, validation, and transfer for novel compounds and complex matrices.
Sample types supported:
We support a diverse range of biologically relevant matrices, including:
- Plasma and serum
- Cerebrospinal fluid (CSF)
- Urine
- Tissue lysates
- Cell and tissue culture supernatants
- Minimally invasive matrices such as dried blood spots (DBS)
Regulatory Compliance and Scientific Excellence
Supporting PK and TK with Proven Expertise
Operating within GLP- and GCP-accredited laboratories, Synexa combines over 20 years of regulated bioanalysis expertise with validated, regulatory-compliant assays, full data traceability, and robust LIMS to support PK and TK studies, delivering a highly consultative, science-driven approach with proven success across global clinical and preclinical programmes, rapid Phase I turnaround, and flexible project management.
20+
Year experience in reguated bioanalysis
Platforms Supporting PK & TK Analysis
We utilise a range of advanced bioanalytical technologies including chromatographic, ligand binding, molecular, and radio-based platforms to generate highly sensitive and reliable pharmacokinetic (PK) and toxicokinetic (TK) data across diverse therapeutic modalities.
dPCR
Digital PCR technology for highly sensitive and precise nucleic acid quantification
MSD S600
High-throughput electrochemiluminescence reader for sensitive multiplex biomarker detection
MSD SQ 120
Compact MSD reader enabling robust electrochemiluminescent immunoassays
WIZARD2 gammacounter
Gamma counter for sensitive radioisotope detection in ligand binding and PK assays
Biacore T200 GxP SPR
Label-free surface plasmon resonance system for real-time biomolecular interaction and binding kinetics analysis
Envision Xcite
Multimode plate reader supporting luminescence, fluorescence and absorbance-based bioassays
Gyrolab xPlore
Automated nanolitre-scale immunoassay platform for rapid, low-volume protein biomarker analysis
Improving the quality of human health
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