Pharmacodynamics (PD)
Advanced pharmacodynamic testing services for biomarker analysis, target engagement, and clinical trial support across all development phases.
Pharmacodynamics Services for Drug Development
Synexa provides comprehensive pharmacodynamics services to support drug development from preclinical through to late-phase clinical trials.
Our integrated approach combines advanced bioanalytical platforms, deep scientific expertise, and access to clinically relevant human samples, enabling robust assessment of drug mechanism, efficacy, and safety.
Pharmacodynamic Applications
Mechanism of Action
Detailed characterisation of drug–target interactions, pathway modulation, and downstream biological effects.
Biomarker Discovery and Qualification
Identification and validation of PD biomarkers to support efficacy, safety, and patient stratification.
Target Engagement and Receptor Occupancy
Quantitative assessment of drug binding and biological activity in blood and tissue samples.
Functional Ex Vivo Testing
Evaluation of drug efficacy and pathway inhibition, including immune activation and signalling pathways.
Longitudinal Monitoring
Real-time tracking of pharmacodynamic responses throughout clinical trials using multiplexed and systems-level approaches.
Sample types supported:
We support a diverse range of biologically relevant matrices, including:
- Plasma and serum
- Cerebrospinal fluid (CSF)
- Urine
- Tissue lysates
- Cell and tissue culture supernatants
- Minimally invasive matrices such as dried blood spots (DBS)
Pharmacodynamic Platforms
We leverage a broad suite of advanced platforms, including MSD, Olink, ELISA, Gyrolab, flow cytometry, LC‑MS/MS, and genomics and cellular assays, to deliver high-sensitivity, multi-dimensional pharmacodynamic insights.
Waters T-QS LC-MS/MS
Tandem mass spectrometry system for sensitive, quantitative small molecule bioanalysis
Waters Premier I-Class UPLC
Ultra-performance liquid chromatography system delivering high-resolution compound separation
BD FacsLyric (12 colours)
Automated flow cytometry system enabling reproducible, high-throughput immunophenotyping
NanoString® nCounter
Digital gene expression platform enabling direct, amplification-free RNA and DNA analysis
dPCR
Digital PCR technology for highly sensitive and precise nucleic acid quantification
MSD S600
High-throughput electrochemiluminescence reader for sensitive multiplex biomarker detection
MSD SQ 120
Compact MSD reader enabling robust electrochemiluminescent immunoassays
Olink Signature q100
Proximity extension assay platform for highly specific, multiplexed protein biomarker profiling
Gyrolab xPlore
Automated nanolitre-scale immunoassay platform for rapid, low-volume protein biomarker analysis
Cytoflex (13 colours)
Flexible flow cytometer enabling sensitive, multiparameter cellular analysis
BD FACSymphony A3 (28 colours)
High-parameter flow cytometer for deep immune profiling and complex cellular phenotyping
Improving the quality of human health
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