Immunogenicity
Comprehensive immunogenicity testing services from Synexa covering ADA, NAb and cellular immune responses across all clinical phases.
Immunogenicity Testing Services
Synexa provides comprehensive immunogenicity testing services across all major laboratory sites, supporting programmes from preclinical development through to late-phase clinical trials.
Our expertise spans both humoral (antibody-mediated) and cellular immune responses, with proven excellence in regulated bioanalysis for biologics, vaccines, cell and gene therapies, and novel modalities, across a wide range of matrices including serum, plasma, CSF, saliva, dried blood spots (DBS), and tissue samples.
Immunogenicity Assays
Anti-Drug Antibody (ADA) and Neutralising Antibody (NAb) Assays
We offer a full tiered anti-drug antibody (ADA) testing strategy, including screening, confirmation, titration, and neutralising antibody (NAb) characterisation. Our NAb assays are available in:
- Ligand-binding formats (ECL, ELISA, Gyrolab)
- Cell-based functional assays for accurate biological response measurement
Cellular Immunogenicity Testing
Our advanced cellular immunogenicity assays enable in-depth profiling of T-cell responses:
- ELISpot and FluoroSpot assays
- Flow cytometry and intracellular cytokine staining (ICS)
Multiplexed Humoral Response Analysis
We provide detailed analysis of immune responses through:
- Isotype and subclass-specific detection (IgG, IgM, IgA)
- Multiplexed platforms including MSD, ELISA, and Gyrolab
Immunogenicity Platforms
We utilise a suite of advanced immunoassay technologies – including MSD, ELISA, Gyrolab, cell-based assays, flow cytometry, and RIA—to deliver sensitive, high-throughput, and functionally relevant immunogenicity data across diverse therapeutic modalities.
MSD S600
High-throughput electrochemiluminescence reader for sensitive multiplex biomarker detection
MSD SQ 120
Compact MSD reader enabling robust electrochemiluminescent immunoassays
WIZARD2 gammacounter
Gamma counter for sensitive radioisotope detection in ligand binding and PK assays
Biacore T200 GxP SPR
Label-free surface plasmon resonance system for real-time biomolecular interaction and binding kinetics analysis
Envision Xcite
Multimode plate reader supporting luminescence, fluorescence and absorbance-based bioassays
Gyrolab xPlore
Automated nanolitre-scale immunoassay platform for rapid, low-volume protein biomarker analysis
Cytoflex (13 colours)
Flexible flow cytometer enabling sensitive, multiparameter cellular analysis
BD FACSymphony A3 (28 colours)
High-parameter flow cytometer for deep immune profiling and complex cellular phenotyping
BD FACSCanto II (8 colours)
Clinical-grade flow cytometer for multiparametric immune cell phenotyping and translational research
Improving the quality of human health
Contact us
Discuss biomarker and bioanalytical solutions to accelerate your therapeutic pipeline
