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From Discovery to Decision: Building a Fit-for-Purpose Proteomics Strategy for Clinical Development

Late-stage clinical trial attrition remains one of the most expensive challenges in drug development, with more than half of Phase III programs failing to meet…

The Biomarker Association between Depression and Vascular Disease

Major depressive disorder (MDD) has repeatedly emerged as a confounding or prognostic factor in the development of cardiovascular pathologies and…

Infertility and the importance of the endometrial immune balance

Infertility is defined by the World Health Organisation as the inability of a sexually active non-contracepting couple, to conceive after…

Immunogenicity 101: Antidrug Antibodies, Neutralising Antibodies, and everything in between

Protein-based biotherapeutic/biologic agents, such as fusion proteins and monoclonal antibodies (mAb) have become the treatment of choice for many indications…

Th17 Cells and IL-17: a possible link between inflammation and neuronal decline in Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS). A major component of the…

Spot on: Use of Dried Blood Spots (DBS) for serological immunoassays

Serological immunoassays provide a complementary approach to PCR-based molecular diagnostics in the detection and monitoring of the immune response of…

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Inflammatory pain and hyperalgesia are considered functional features of an immune response, intended to protect tissue from further damage. At…

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