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Protein Degraders: Small Molecules Taking out the Trash

A single PROTAC molecule has two different binding ligands attached by a linker. One ligand binds to the target protein and the other recruits an…

Th17 Cells and IL-17: a possible link between inflammation and neuronal decline in Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS). A major component of the…

Spot on: Use of Dried Blood Spots (DBS) for serological immunoassays

Serological immunoassays provide a complementary approach to PCR-based molecular diagnostics in the detection and monitoring of the immune response of…

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Inflammatory pain and hyperalgesia are considered functional features of an immune response, intended to protect tissue from further damage. At…

The prospect of immunotherapy for combating Alzheimer’s disease

Alzheimer’s disease is a progressive incurable neurodegenerative disorder that often leads to dementia, loss of motor function and cognitive decline.…

Rapid expansion of Treg cells protects from collateral colitis following a viral trigger

Regulatory T (Treg) cells are important for the induction and maintenance of peripheral tolerance; therefore, they are key in preventing…

Immune biomarkers in depression

The identification of clinically relevant and reproducible biomarkers in the field of psychiatry has received increased attention recently in order…

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