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Protein Degraders: Small Molecules Taking out the Trash

A single PROTAC molecule has two different binding ligands attached by a linker. One ligand binds to the target protein and the other recruits an…

Faecal Calprotectin as a biomarker in Crohn’s disease

Crohn’s disease is an inflammatory bowel disease, which causes inflammation of your digestive tract with symptoms such as abdominal pain,…

Immune checkpoint inhibitors and MDSCs

The development of immune checkpoint inhibitors (ICIs) targeting lymphoid cells has remarkedly transformed therapeutic approaches for the treatment of cancer.…

Potential concussion biomarkers discovered in circulating blood after brain injury

Concussions are a commonly diagnosed injury in many sports, particularly at college or professional levels. While the diagnosis of a…

Complement C4 Genes and Sex-Biased Disease Susceptibility

There are many examples of diseases in which there is a sex bias, however, the underlying biology of this bias…

A unifying expression signature for SLE

Systemic Lupus Erythematosus (SLE) is an inflammatory autoimmune condition characterised by a wide variety of symptoms including skin rashes, oral…

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