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From Detection to Decision: Risk-Based Immunogenicity Testing

Immunogenicity describes treatment‑induced B‑ and T‑cell responses to therapeutics and represents a major hurdle for drug development, due to the potential impact on patient safety…

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Inflammatory pain and hyperalgesia are considered functional features of an immune response, intended to protect tissue from further damage. At…

The prospect of immunotherapy for combating Alzheimer’s disease

Alzheimer’s disease is a progressive incurable neurodegenerative disorder that often leads to dementia, loss of motor function and cognitive decline.…

Rapid expansion of Treg cells protects from collateral colitis following a viral trigger

Regulatory T (Treg) cells are important for the induction and maintenance of peripheral tolerance; therefore, they are key in preventing…

Immune biomarkers in depression

The identification of clinically relevant and reproducible biomarkers in the field of psychiatry has received increased attention recently in order…

Faecal Calprotectin as a biomarker in Crohn’s disease

Crohn’s disease is an inflammatory bowel disease, which causes inflammation of your digestive tract with symptoms such as abdominal pain,…

Immune checkpoint inhibitors and MDSCs

The development of immune checkpoint inhibitors (ICIs) targeting lymphoid cells has remarkedly transformed therapeutic approaches for the treatment of cancer.…

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