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Why Preclinical Formulation Analysis is Critical to Successful Drug Development

Preclinical studies are designed to establish the safety profile and biological activity of a therapeutic candidate before human testing can begin. The interpretation of these…
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Immunogenicity 101: Antidrug Antibodies, Neutralising Antibodies, and everything in between

Protein-based biotherapeutic/biologic agents, such as fusion proteins and monoclonal antibodies (mAb) have become the treatment of choice for many indications…
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Th17 Cells and IL-17: a possible link between inflammation and neuronal decline in Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of the central nervous system (CNS). A major component of the…
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Spot on: Use of Dried Blood Spots (DBS) for serological immunoassays

Serological immunoassays provide a complementary approach to PCR-based molecular diagnostics in the detection and monitoring of the immune response of…
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Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Inflammatory pain and hyperalgesia are considered functional features of an immune response, intended to protect tissue from further damage. At…
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The prospect of immunotherapy for combating Alzheimer’s disease

Alzheimer’s disease is a progressive incurable neurodegenerative disorder that often leads to dementia, loss of motor function and cognitive decline.…
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Rapid expansion of Treg cells protects from collateral colitis following a viral trigger

Regulatory T (Treg) cells are important for the induction and maintenance of peripheral tolerance; therefore, they are key in preventing…
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