Flow Cytometry Services
Flow Cytometry Services
Illuminating insights
Synexa’s flow cytometric expertise will provide the data needed to get your therapeutic to market and provide patients with the treatment they deserve.
Flow cytometry is a rich source of clinical research data, providing valuable data down to a single cell level, unearthing a multitude of interactions and links through in-depth analysis.
Synexa specialises in bespoke flow cytometry panels in early phase preclinical and clinical trial research and is positioned at the forefront of the rapidly expanding field of flow cytometry. Led by leaders in the field with decades of experience, our labs are supported by robust and proven technology platforms, harmonized across our strategically located labs to ensure effective transfer of methods and protocols with a focus on specialised training and in-depth method validation, thus supporting our clients with quality, scientifically-sound and clinically-relevant data.
We tailor our assays to our clients’ needs, developing and validating novel de novo methods where required. Clinical samples from a wide range of matrices can be processed fresh, or cryopreserved for later batch processing and analysed with any of a range of sophisticated assays, including multimer, phospho-flow cytometry and receptor occupancy assays. Our sites not only have dedicated PBMC processing units, but are also linked to BSL2 level cell culture laboratories.
We pride ourselves in determining the best strategy according to the clients’ needs at the pre-analytical phase of a study, thus ensuring that downstream analysis accurately reflects clinically-relevant biology and provides useful and relevant information to improve decision making.
Flow cytometry applications
Analytical assay capabilities:
We are fully capable of managing samples through the complete analytical cycle, with
dedicated project, logistics and sample management policies.
- Immuno-profiling & phenotyping assays
- Lymphocytes (TN, TH, TFH, Treg, TEFF, TEM, TCM, NK & B cells)
- Dendritic Cells (DCs)
- Monocytes
- Macrophages
- Myeloid-derived suppressor cells (MDSCs)
- Multimers
- Intracellular staining
- Treg polarization assessment
- Target engagement/PK/PD assays
- Receptor Occupancy (RO) assays
- Phospho-flow assays
- Polyamine uptake assessment
- SARS-CoV-2 immune response assessment
- Flow cytometry-based PK assessment
- Function assays
- Cytokine expression
- Cytotoxic markers
- Activation markers
- Proliferation assays
- Basophil degranulation
- Rare cell detection and quantification
- Antibody-dependant cellular cytotoxicity (ADCC)
- Complement-dependant cytotoxicity (CDC)
- Small particle detection and analysis
- ELISpot assays
As with all work that we do at Synexa, these applications can be fully customized according to your needs and endpoint objectives.
Instrument platforms
Robust and proven platforms
Our technology platforms are robust, reliable and reputable in the clinical field and provide comprehensive and detailed data readouts for your application.
BD FACSCanto II
(8 colours)
BD FACSymphony A3
(30 colours)
BD FACSCanto I
(10 colours)
